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Thyroid : Official Journal of the... Oct 2011
Topics: Antibodies; Female; Humans; Hypothyroidism; Mass Screening; Postpartum Period; Postpartum Thyroiditis; Pregnancy; Pregnancy Complications; Societies, Medical; Thyroid Diseases; Thyroid Gland; United States
PubMed: 21787128
DOI: 10.1089/thy.2011.0087 -
Frontiers in Endocrinology 2022
Topics: Humans; Hypothyroidism; Thyroid Diseases
PubMed: 35937814
DOI: 10.3389/fendo.2022.980585 -
Medicina (Kaunas, Lithuania) Oct 2023: Thyroid disease has been associated with autoimmune disorders. As systemic lupus erythematosus (SLE) is a systemic autoimmune disease with diverse manifestations...
: Thyroid disease has been associated with autoimmune disorders. As systemic lupus erythematosus (SLE) is a systemic autoimmune disease with diverse manifestations spanning across all organ systems, the relationship of SLE with thyroid disorders needs investigation. In particular, the relationship of SLE with autoimmune thyroid disease has attracted the interest of the research community. The aim was to evaluate the relationship of SLE with autoimmune thyroid disease. : A cohort of 45 consecutive patients with a mean age of 47.97 years (range 21-79 years) and 45 age- and sex-matched controls were prospectively studied over a period of 12 months for the presence of thyroid disease and the prevalence of antithyroid antibodies. : Four patients (8.9%) were found to suffer from primary hypothyroidism, five (11.11%) from subclinical hypothyroidism and one (2.22%) from hyperthyroidism, whereas one (2.22%) of the controls had primary hypothyroidism and one (2.22%) had hyperthyroidism. Five patients (11.11%) had a thyroid hormone profile that was compatible with the presence of euthyroid sick syndrome. Thyroid peroxidase (TPOab) and thyroglobulin (Tgab) antibodies were detected in 20/45 and 15/45 of the SLE population and in 7/45 and 5/45 of the controls, respectively ( < 0.05, chi-square test). : In conclusion, the incidence of clinical thyroid disease is greater amongst SLE patients than in a control population, and in a significant number of these patients, antithyroid antibodies are detectable. Thus, a subset of lupus patients appears to be predisposed to the development of thyroid disease, and this should be considered when evaluating patients with SLE.
Topics: Humans; Infant; Child, Preschool; Child; Thyroid Diseases; Hypothyroidism; Hyperthyroidism; Thyroid Hormones; Lupus Erythematosus, Systemic; Autoantibodies
PubMed: 38003960
DOI: 10.3390/medicina59111911 -
Frontiers in Immunology 2020
Topics: Aging; Animals; Disease Management; Disease Susceptibility; Humans; Stress, Physiological; Stress, Psychological; Thymus Gland; Thyroid Diseases
PubMed: 33193434
DOI: 10.3389/fimmu.2020.591936 -
Purinergic Signalling Mar 2023It is known that thyroid hormones play pivotal roles in a wide variety of pathological and physiological events. Thyroid diseases, mainly including hyperthyroidism,... (Review)
Review
It is known that thyroid hormones play pivotal roles in a wide variety of pathological and physiological events. Thyroid diseases, mainly including hyperthyroidism, hypothyroidism, and thyroid cancer, are highly prevalent worldwide health problems and frequently associated with severe clinical manifestations. However, etiology of hyperthyroidism, hypothyroidism, and thyroid cancer is not fully understood. Purinergic signaling accounts for a complex network of receptors and extracellular enzymes responsible for the recognition and degradation of extracellular nucleotides and adenosine. It has been established that purinergic signaling modulates pathways in a wide range of physiopathological conditions including hypertension, diabetes, hepatic diseases, psychiatric and neurodegeneration, rheumatic immune diseases, and cancer. More recently, the purinergic system is found to exist in thyroid gland and play an important role in the pathophysiology of thyroid diseases. Therefore, throughout this review, we focus on elaborating the changes in purinergic receptors, extracellular enzymes, and extracellular nucleotides and adenosine in hyperthyroidism, hypothyroidism, and thyroid cancer. Profound understanding of the relationship between the purinergic signaling with thyroid diseases provides a promising research area for insights into the molecular basis of thyroid diseases and also develops new and exciting insights into the treatment of thyroid diseases, especially thyroid cancer.
Topics: Humans; Nucleotides; Adenosine; Hypothyroidism; Hyperthyroidism; Thyroid Neoplasms
PubMed: 35347568
DOI: 10.1007/s11302-022-09858-2 -
Missouri Medicine 2022
Topics: Humans; Thyroid Diseases
PubMed: 36118808
DOI: No ID Found -
Ugeskrift For Laeger May 2023Acquired hypothyroidism is the most common thyroid disease in paediatric patients and in iodine-replete areas mainly due to autoimmune thyroiditis (AIT). Symptoms of... (Review)
Review
Acquired hypothyroidism is the most common thyroid disease in paediatric patients and in iodine-replete areas mainly due to autoimmune thyroiditis (AIT). Symptoms of hypothyroidism are unspecific and insidious for which reason thyroid function tests are often part of a general paediatric assessment. Consequently, only few patients present with pronounced symptoms which include a stunted growth pattern and multiorgan involvement when most extreme. This review provides an overview of the current knowledge on this common endocrinopathy in childhood.
Topics: Humans; Child; Adolescent; Hypothyroidism; Thyroid Diseases; Thyroiditis, Autoimmune; Iodine
PubMed: 37264859
DOI: No ID Found -
Medicine Nov 2023Observational studies have reported some associations between thyroid disease and gout, but the causal relationship between the 2 is not clear. We used Mendelian...
Observational studies have reported some associations between thyroid disease and gout, but the causal relationship between the 2 is not clear. We used Mendelian randomization (MR) Analysis to investigate the causal association between some thyroid diseases (autoimmune hypothyroidism, autoimmune hyperthyroidism, thyroid nodules, and thyroid cancer) and gout. GWAS data were used for analysis. The exposure factors were autoimmune hypothyroidism, autoimmune hyperthyroidism, thyroid nodules and thyroid cancer, and the outcome variables were gout. IVW, MR-Egger, Weighted median and Weighted mode were used for MR analysis. Cochran Q test MR-PRESSO and MR-Egger intercept analysis were used to detect heterogeneity and multi directivity. Autoimmune hypothyroidism has a causal effect on gout, IVW results show (OR = 1.13, 95% CI = 1.03-1.21, PFDR = 0.0336); Autoimmune hyperthyroidism has a causal effect on gout, IVW results show (OR = 1.07, 95% CI = 1.01-1.12, PFDR = 0.0314); Thyroid cancer has no causal effect on gout, IVW results show (OR = 1.03, 95% CI = 0.98-1.09, PFDR = 0.297); Thyroid nodules has no causal effect on gout, IVW results show (OR = 1.03, 95% CI = 0.98-1.08, PFDR = 0.225); Reverse MR Studies show that gout have no causal effect on the above thyroid diseases. Autoimmune hypothyroidism and autoimmune hyperthyroidism increase the risk of gout.
Topics: Humans; Thyroid Nodule; Mendelian Randomization Analysis; Thyroid Neoplasms; Graves Disease; Gout; Hypothyroidism; Genome-Wide Association Study
PubMed: 37932979
DOI: 10.1097/MD.0000000000035817 -
British Journal of Anaesthesia Jul 2000In summary, disease of the thyroid gland is common. Anaesthetists will be required to manage patients with hypothyroidism and hyperthyroidism and those requiring... (Review)
Review
In summary, disease of the thyroid gland is common. Anaesthetists will be required to manage patients with hypothyroidism and hyperthyroidism and those requiring thyroidectomy. Since anaesthesia for thyroidectomy provides many challenges of airway management, the anaesthetist should pay particular attention to preoperative assessment of the airway and should be able to deal with acute airway complications in the perioperative phase.
Topics: Anesthesia; Humans; Postoperative Complications; Preoperative Care; Thyroid Diseases; Thyroidectomy
PubMed: 10927992
DOI: 10.1093/bja/85.1.15 -
Endocrine May 2020
Topics: Autoimmune Diseases; Hashimoto Disease; Humans; Thyroid Diseases
PubMed: 32052368
DOI: 10.1007/s12020-020-02188-6